February 4, 2023

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The first experimental transplant operation of a man’s pig kidney was successfully performed


20 October 2021 14:00 GMT

This procedure represents a significant improvement in the treatment of critically ill patients to alleviate the shortage of transplants.

For the first time in history, a team of U.S. surgeons has successfully transplanted a swine kidney into a human, as part of a testing procedure conducted last month at New York University’s Langon Health Medical Center, the company said on Wednesday. Reuters.

Pork kidneys have long been used in medicine, but a sugar in their cells, galactose-alpha-1,3-galactose (also known as alpha-gale), is present in all mammals except humans and other animals. Immediate immune rejection.

The recent process involving the genetically modified Calzoff pig’s kidney marks a significant breakthrough in the search for possible alternatives to alleviate organ organ deficiency in critically ill patients.

The organ was transplanted into one’s body The woman who reached the brain drain, Combined with an artificial respirator and symptoms Kidney failure. His family agreed to the experiment before his life support could be discontinued. Robert Montgomery, who led the surgical team, proved that within three days of the kidney being connected to the recipient’s blood vessels, it was functioning and “seemed very normal.”

The The amount of creatine Characterization of impaired renal function was confirmed after intervention and new organ production “Expected Urine Level” Transplanted human kidney. The doctor said there were no signs of premature rejection. It is noteworthy that the research has not yet been reviewed or published in the medical journal.

The United Network, a non-profit organization that manages organ transplants in the United States, says there are about 107,000 people on the waiting list. 90,000 people are trying to get a kidney. On average, three to five years is the time it takes to get the latter answer; Relying on difficult dialysis treatment is a time of death for many who need it.

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Not only is it an obviously viable solution to the apparent shortage of elements, but the progress made by Montgomery and his team is a significant step in this field. xenotrasplantes (Transplantation of cells, tissues or organs between different organismsThose who have always faced various obstacles, including physiological compatibility and immune rejection.

US Food and Drug Administration (FDA) last December Approved The use of calfskin pigs for food and medical purposes, the company warned further Specific approval required For alternative treatment in the living population, the company collects A.P..

At the same time, there is a need to develop ethical and political guidelines for this practice around the welfare and exploitation of animals. Either way, experts say this test could pave the way for the first trial transplant in the next few years.

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